Author's response to reviews Title: Loss of heterozygosity at the ATBF1-A locus located in the 16q22 minimal region in breast cancer Authors:
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Author's response to reviews Title: LOH at 6q and 10q in Fractionated Circulating DNA of Ovarian Cancer Patients is Predictive for Tumor Cell Spread and Overall Survival Authors:
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ATBF1-a messenger RNA expression is correlated with better prognosis in breast cancer.
PURPOSE The AT motif-binding factor 1 (ATBF1) gene was first identified as a suppressor of the alpha-fetoprotein (AFP) gene through its binding to an AT-rich enhancer element of this gene. The gene is located at chromosome 16q22.3-q23.1 where loss of heterozygosity has been observed in various malignant tumors, especially in breast cancer. It was also found that in highly malignant AFP-producin...
متن کاملAuthor's response to reviews Title: Loss of miR-133a expression associated with poor survival of breast cancer and restoration of miR-133a expression inhibited breast cancer cell growth and invasion Authors:
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Genetic alterations of the ATBF1 gene in gastric cancer.
PURPOSE Alpha-fetoprotein (AFP)-producing gastric cancers are aggressive tumors with venous and lymphatic invasion and hepatic metastasis. The goal of the present study was to investigate whether somatic changes of the AFP-negative regulator AT motif binding factor-1 (ATBF1) gene are involved in the development or progression of gastric cancers and the production of AFP in gastric cancer cells....
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